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Stomatologija 2017; 19 (3):91-6 141 KB

Serum and salivary lactate dehydrogenase levels as biomarkers of tissue damage among cigarette smokers. A biochemical study

Kumuda Rao¹, Subhas G. Babu¹, Urvashi A. Shetty², Renita Lorina Castelino¹, Shishir Ram Shetty³

Summary

Objective. To estimate the serum and salivary lactate dehydrogenase levels in cigarette smokers and non-smokers.

Materials and Methods. In this study lactate dehydrogenase levels were estimated in 30 healthy individuals with no tobacco related habits and in 30 patients with history of smoking cigarettes for a minimum of 2 years using Spectrophotometry.

Results. The mean values for serum and salivary lactate dehydrogenase levels were higher in cigarette smokers when compared to non-smokers. Serum lactate dehydrogenase levels on comparison between the groups was statistically significant (p=0.04). The values of salivary lactate dehydrogenase levels between the groups was highly significant (p<0.001).

Conclusion. Cigarette smoking leads to an increase in serum as well as salivary Lactate dehydrogenase levels as indicator of tissue damage in the oral cavity. The present study indicates saliva as a better test medium than serum in determination of lactate dehydrogenase levels.

Key words: antioxidants, saliva, serum, cigarette smoking, lactate dehydrogenase.

Received: 19 08 2016

Accepted for publishing: 28 09 2017

¹Department of Oral Medicine and Radiology, A. B. Shetty Memorial Institute of Dental Sciences, Nitte University, Deralakatte, India

²Department of Oral Pathology and Microbiology, A. B. Shetty Memorial Institute of Dental Sciences, Nitte University, Deralakatte, India

³Department of Oral Medicine and Radiology, Gulf Medical University, Ajman, United Arab Emirates

Address correspondence to Dr. Kumuda Rao, A. B. Shetty Memorial Institute of Dental Sciences, Nitte University, Deralakatte, Mangalore, Karnataka, India.

E-mail address: drkumudarao@yahoo.in



	Baltic Dental and Maxillofacial Journal

September, 2017, Vol. 19, No. 3 CONTENTS SCIENTIFIC ARTICLES Signalling molecules in jaw bones and gingival tissues of patients with Class II and Class III dentofacial deformities Iveta Jankovska, Mara Pilmane, Ilga Urtane 71-77 Family history and risk factors for cleft lip and palate patients and their associated anomalies Abdolreza Jamilian, Farzin Sarkarat, Mehrdad Jafari, Morteza Neshandar, Ehsan Amini, Saeed Khosravi, Alireza Ghassemi 78-83 Psychosocial factors correlated with children’s dental anxiety Līga Kroniņa, Malgožata Rasčevska, Rūta Care 84-90 Serum and salivary lactate dehydrogenase levels as biomarkers of tissue damage among cigarette smokers. A bochemical study Kumuda Rao, Subhas Babu, Urvashi A. Shetty, Renita Lorina Castelino, Shishir Ram Shetty 91-96 CASE REPORT Histopathological and microradiological features of peri-implantits. A case report Mustafa Ayna, Aydin Gulses, Yahya Açili 97-100 © 2017 Stomatologija		Stomatologija 2017; 19 (3):91-6 141 KB Serum and salivary lactate dehydrogenase levels as biomarkers of tissue damage among cigarette smokers. A biochemical study Kumuda Rao¹, Subhas G. Babu¹, Urvashi A. Shetty², Renita Lorina Castelino¹, Shishir Ram Shetty³ Summary Objective. To estimate the serum and salivary lactate dehydrogenase levels in cigarette smokers and non-smokers. Materials and Methods. In this study lactate dehydrogenase levels were estimated in 30 healthy individuals with no tobacco related habits and in 30 patients with history of smoking cigarettes for a minimum of 2 years using Spectrophotometry. Results. The mean values for serum and salivary lactate dehydrogenase levels were higher in cigarette smokers when compared to non-smokers. Serum lactate dehydrogenase levels on comparison between the groups was statistically significant (p=0.04). The values of salivary lactate dehydrogenase levels between the groups was highly significant (p<0.001). Conclusion. Cigarette smoking leads to an increase in serum as well as salivary Lactate dehydrogenase levels as indicator of tissue damage in the oral cavity. The present study indicates saliva as a better test medium than serum in determination of lactate dehydrogenase levels. Key words: antioxidants, saliva, serum, cigarette smoking, lactate dehydrogenase. Received: 19 08 2016 Accepted for publishing: 28 09 2017 ¹Department of Oral Medicine and Radiology, A. B. Shetty Memorial Institute of Dental Sciences, Nitte University, Deralakatte, India ²Department of Oral Pathology and Microbiology, A. B. Shetty Memorial Institute of Dental Sciences, Nitte University, Deralakatte, India ³Department of Oral Medicine and Radiology, Gulf Medical University, Ajman, United Arab Emirates Address correspondence to Dr. Kumuda Rao, A. B. Shetty Memorial Institute of Dental Sciences, Nitte University, Deralakatte, Mangalore, Karnataka, India. E-mail address: drkumudarao@yahoo.in