www.sbdmj.com - Stomatologija - Baltic Dental and Maxillofacial Journal

Stomatologija 2017; 19 (3):78-83 33 KB

Family history and risk factors for cleft lip and palate patients and their associated anomalies

Abdolreza Jamilian¹, Farzin Sarkarat², Mehrdad Jafari³, Morteza Neshandar⁴, Ehsan Amini⁵, Saeed Khosravi⁶, Alireza Ghassemi⁷

Summary

Background and aims. Several environmental and genetic issues have been suspected as risk factors for oral clefts; and many studies have been conducted in this regard; however, large socioeconomic impacts of cleft lip and or palate (CL/P) justifies the need for further multifactorial researches. Current study aimed to assess parental risk factors for CL/P and its associated malformations.

Material and Methods. Hospital records of 187 consecutive syndromic and non-syndromic children with cleft lip and or palate (103 boys and 84 girls) with a mean age of 1.7 (SD 2.2) years and 190 consecutive non-cleft children (103 boys and 87 girls) with a mean age of 2.8 (SD 2.2) years formed this study. Parental risk factors and abnormalities and physical problems and anomalies were evaluated in all subjects.

Results. Family history of clefts (OR 7.4; 95% CI), folic acid consumption (OR 7.3; 95% CI) and consanguineous marriage (OR 3.2; 95% CI) were quite strongly associated with increased risk of CL/P. In addition, all congenital abnormalities and physical problems had significantly higher incidence in CL/P patients.

Conclusions. The findings of this study suggest that expecting mothers of consanguineous marriage and families with a history of CL/P should be extra cautious about the occurrence of CL/P.

Key words: family history, risk factors, cleft lip and palate.

Received: 21 06 2016

Accepted for publishing: 28 09 2017

¹Orthodontic department, Craniomaxillofacial research center, Tehran Dental Branch, Islamic Azad University, Tehran, Iran

²Oral and maxillofacial surgery department, Craniomaxillofacial research center, Tehran Dental Branch, Islamic Azad University, Tehran, Iran

³ENT department, Tehran University of Medical Sciences, Medical Center of Imam Khomeini Hospital, Tehran, Iran

⁴Department of prosthodontics, Craniomaxillofacial research center, Tehran Dental Branch, Islamic Azad University, Tehran, Iran

⁵Craniomaxillofacial research center, Tehran Dental Branch, Islamic Azad University, Tehran, Iran

⁶Department of languages, Tehran University of Medical Sciences, Tehran, Iran

⁷Department of Oral, Maxillofacial Plastic and Reconstructive Surgery, University Hospital, Aachen, Germany

Address correspondence to Dr Abdolreza Jamilian. No 14, Pesiyan St., Vali Asr St. Tehran 1986944768, Iran.

E-mail address: info@jamilian.net



	Baltic Dental and Maxillofacial Journal

September, 2017, Vol. 19, No. 3 CONTENTS SCIENTIFIC ARTICLES Signalling molecules in jaw bones and gingival tissues of patients with Class II and Class III dentofacial deformities Iveta Jankovska, Mara Pilmane, Ilga Urtane 71-77 Family history and risk factors for cleft lip and palate patients and their associated anomalies Abdolreza Jamilian, Farzin Sarkarat, Mehrdad Jafari, Morteza Neshandar, Ehsan Amini, Saeed Khosravi, Alireza Ghassemi 78-83 Psychosocial factors correlated with children’s dental anxiety Līga Kroniņa, Malgožata Rasčevska, Rūta Care 84-90 Serum and salivary lactate dehydrogenase levels as biomarkers of tissue damage among cigarette smokers. A bochemical study Kumuda Rao, Subhas Babu, Urvashi A. Shetty, Renita Lorina Castelino, Shishir Ram Shetty 91-96 CASE REPORT Histopathological and microradiological features of peri-implantits. A case report Mustafa Ayna, Aydin Gulses, Yahya Açili 97-100 © 2017 Stomatologija		Stomatologija 2017; 19 (3):78-83 33 KB Family history and risk factors for cleft lip and palate patients and their associated anomalies Abdolreza Jamilian¹, Farzin Sarkarat², Mehrdad Jafari³, Morteza Neshandar⁴, Ehsan Amini⁵, Saeed Khosravi⁶, Alireza Ghassemi⁷ Summary Background and aims. Several environmental and genetic issues have been suspected as risk factors for oral clefts; and many studies have been conducted in this regard; however, large socioeconomic impacts of cleft lip and or palate (CL/P) justifies the need for further multifactorial researches. Current study aimed to assess parental risk factors for CL/P and its associated malformations. Material and Methods. Hospital records of 187 consecutive syndromic and non-syndromic children with cleft lip and or palate (103 boys and 84 girls) with a mean age of 1.7 (SD 2.2) years and 190 consecutive non-cleft children (103 boys and 87 girls) with a mean age of 2.8 (SD 2.2) years formed this study. Parental risk factors and abnormalities and physical problems and anomalies were evaluated in all subjects. Results. Family history of clefts (OR 7.4; 95% CI), folic acid consumption (OR 7.3; 95% CI) and consanguineous marriage (OR 3.2; 95% CI) were quite strongly associated with increased risk of CL/P. In addition, all congenital abnormalities and physical problems had significantly higher incidence in CL/P patients. Conclusions. The findings of this study suggest that expecting mothers of consanguineous marriage and families with a history of CL/P should be extra cautious about the occurrence of CL/P. Key words: family history, risk factors, cleft lip and palate. Received: 21 06 2016 Accepted for publishing: 28 09 2017 ¹Orthodontic department, Craniomaxillofacial research center, Tehran Dental Branch, Islamic Azad University, Tehran, Iran ²Oral and maxillofacial surgery department, Craniomaxillofacial research center, Tehran Dental Branch, Islamic Azad University, Tehran, Iran ³ENT department, Tehran University of Medical Sciences, Medical Center of Imam Khomeini Hospital, Tehran, Iran ⁴Department of prosthodontics, Craniomaxillofacial research center, Tehran Dental Branch, Islamic Azad University, Tehran, Iran ⁵Craniomaxillofacial research center, Tehran Dental Branch, Islamic Azad University, Tehran, Iran ⁶Department of languages, Tehran University of Medical Sciences, Tehran, Iran ⁷Department of Oral, Maxillofacial Plastic and Reconstructive Surgery, University Hospital, Aachen, Germany Address correspondence to Dr Abdolreza Jamilian. No 14, Pesiyan St., Vali Asr St. Tehran 1986944768, Iran. E-mail address: info@jamilian.net