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Stomatologija 2014; 16 (4): 153-160 527 KB

Biologically active substances in bone morphogenesis. Literature review

Stasys Bojarskas, Regimantas Simuntis

Summary

Objectives. Understanding the mechanisms of bone morphogenesis is essential in solving problems related to reconstruction of bone defects. In a field of bone morphogenesis enormous array of biologically active substances have been proved as having more or less influence on bone growth, but no ideal guiding path for a new bone formation has been established yet. Therefore, bone tissue engineering, based on the laws of osteogenesis, becomes a significant niche for investigation. The aim of this article is to review recent scientific information concerning the role of bio substances in osteogenesis, their potentials in and future prospects.

Material and methods. Medline library database was searched, focusing on stem cells, osteoblast differentiation, bone growth factors and bone tissue engineering. Limits were review, research support. A quality assessment was carried out.

Results. A total of 63 articles matching our criteria were found: 20 reviews summarizing topics of growth factors, stem cells, tissue engineering and 43 articles representing studies of growth factors impact in osteoblast differentiation, bone regeneration and bone engineering.

Conclusions. The interactions among growth factors in osteoblast differentiation cascade are not fully understood. Moreover, methods of conversion of laboratory processes into clinically effective, reproducible, safe, economically viable and competitive products need to be improved.

Key words: bone morphogenesis, bone tissue engineering, growth factors, mesenchymal stem cells.

Received: 14 06 2014

Accepted for publishing: 20 12 2014

^*Clinic of Maxillofacial Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania

Stasys Bojarskas^* – D.D.S., PhD, assoc. prof.

Regimantas Simuntis^* – D.D.S.

Address correspondence to Dr. Stasys Bojarskas, Department of oral and maxillofacial surgery, Lithuanian University of Health Sciences, Kaunas Clinics, Eiveniu str. 2, LT-50009 Kaunas, Lithuania.

E-mail address: litmaxfac@yahoo.com



	Baltic Dental and Maxillofacial Journal

December, 2014, Vol. 16, No. 4 CONTENTS REVIEWS Hemophilia and oral health Ruta Zaliuniene, Vytaute Peciuliene, Vilma Brukiene, Jolanta Aleksejuniene 127-131 SCIENTIFIC ARTICLES IRF6 AP-2a binding site promoter polymorphism is associated with oral clefts in Latvia Kristīne Krasone, Baiba Lāce, Ilze Akota, Rūta Care, Kathleen Deeley, Erika C. Küchler, Alexandre R. Vieira 132-136 Mandibular morphology in monozygotic twins: a cephalometric study Mantas Šidlauskas, Loreta Šalomskienė, Irena Andriuškevičiūtė, Monika Šidlauskienė, Žygimantas Labanauskas, Antanas Šidlauskas 137-143 Quality management and job related factors predicting satisfaction of dental clinic staff in Estonia Eda Merisalu, Georg Männik, Kaja Põlluste 144-152 REVIEWS Biologically active substances in bone morphogenesis. Literature review Stasys Bojarskas, Regimantas Simuntis 153-160 © 2014 Stomatologija		Stomatologija 2014; 16 (4): 153-160 527 KB Biologically active substances in bone morphogenesis. Literature review Stasys Bojarskas, Regimantas Simuntis Summary Objectives. Understanding the mechanisms of bone morphogenesis is essential in solving problems related to reconstruction of bone defects. In a field of bone morphogenesis enormous array of biologically active substances have been proved as having more or less influence on bone growth, but no ideal guiding path for a new bone formation has been established yet. Therefore, bone tissue engineering, based on the laws of osteogenesis, becomes a significant niche for investigation. The aim of this article is to review recent scientific information concerning the role of bio substances in osteogenesis, their potentials in and future prospects. Material and methods. Medline library database was searched, focusing on stem cells, osteoblast differentiation, bone growth factors and bone tissue engineering. Limits were review, research support. A quality assessment was carried out. Results. A total of 63 articles matching our criteria were found: 20 reviews summarizing topics of growth factors, stem cells, tissue engineering and 43 articles representing studies of growth factors impact in osteoblast differentiation, bone regeneration and bone engineering. Conclusions. The interactions among growth factors in osteoblast differentiation cascade are not fully understood. Moreover, methods of conversion of laboratory processes into clinically effective, reproducible, safe, economically viable and competitive products need to be improved. Key words: bone morphogenesis, bone tissue engineering, growth factors, mesenchymal stem cells. Received: 14 06 2014 Accepted for publishing: 20 12 2014 ^Clinic of Maxillofacial Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania Stasys Bojarskas^ – D.D.S., PhD, assoc. prof. Regimantas Simuntis^* – D.D.S. Address correspondence to Dr. Stasys Bojarskas, Department of oral and maxillofacial surgery, Lithuanian University of Health Sciences, Kaunas Clinics, Eiveniu str. 2, LT-50009 Kaunas, Lithuania. E-mail address: litmaxfac@yahoo.com