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Stomatologija 2023; 25 (1): 11-20 237 KB

Systemic and topical treatment methods of recurrent aphthous stomatitis: A systematic review

Karolis Skučas¹, Aušra Balčiūnaitė², Nomeda Basevičienė²

Summary

Aim. To analyze the latest systemic and topical recurrent aphthous stomatitis (RAS) treatment methods that could help patients in their daily lives.

Material and methods. A systematic literature review was performed of randomized control trials in English identified in MEDLINE (PubMed), Cochrane Central Register of Controlled Trials (Cochrane Library), Researchgate, published between 2018 and 2023. Studies had to be performed in vivo.

Results. 34 randomized clinical trials matched all criterias and were included in systematic literature review. A wide variety of topical and systemic agents are suggested for the treatment of RAS.

Conclusion. Topical medications can promote the healing time of ulcers and relieve the pain, but most of the time can not decrease the frequency of RAS relapse. However, for continuous RAS, treatment with systemic medication should be considered.

Key words: reccurent, aphthous, stomatitis, RAS, treatment, systematic review.

Received: 09 05 2022

Accepted for publishing: 24 03 2023

¹UAB “SB dantu klinika”, LT49452 Kaunas, Lithuania

²Department of Dental and Oral Pathology, Lithuanian University of Health Sciences, Kaunas, Lithuania

Address correspondence to Karolis Skučas, Faculty of Odontology, Medical Academy, Lithuanian University of Health Sciences, Taikos pr. 65-23, 50436 Kaunas, Lithuania.

E-mail address: karolissk@gmail.com



	Baltic Dental and Maxillofacial Journal

2023, Vol. 25, No. 1 CONTENTS SCIENTIFIC ARTICLE Pilot study: Correlation between nasalance scores and cephalometric parameters in Estonian cleft palate children Lagle Lehes, Carina Aria, Marika Padrik, Priit Kasenõmm, Triin Jagomägi 3-10 REVIEW Systemic and topical treatment methods of recurrent aphthous stomatitis: A systematic review Karolis Skučas, Aušra Balčiūnaitė, Nomeda Basevičienė 11-20 SCIENTIFIC ARTICLE Comparative characteristics of the properties of dental implants depending on the design, shape and surface in the experiment Dmytro Kaplun, David Avetikov, Кateryna Lokesv, Olena Ivanytska 21-25 CASE REPORT Dermatofibrosarcoma protuberans: A rare presentation in the scalp. Case report Akmal A, Balamurugan Rajendran, Kaleem Ajmal 26-28 © 2023 Stomatologija		Stomatologija 2023; 25 (1): 11-20 237 KB Systemic and topical treatment methods of recurrent aphthous stomatitis: A systematic review Karolis Skučas¹, Aušra Balčiūnaitė², Nomeda Basevičienė² Summary Aim. To analyze the latest systemic and topical recurrent aphthous stomatitis (RAS) treatment methods that could help patients in their daily lives. Material and methods. A systematic literature review was performed of randomized control trials in English identified in MEDLINE (PubMed), Cochrane Central Register of Controlled Trials (Cochrane Library), Researchgate, published between 2018 and 2023. Studies had to be performed in vivo. Results. 34 randomized clinical trials matched all criterias and were included in systematic literature review. A wide variety of topical and systemic agents are suggested for the treatment of RAS. Conclusion. Topical medications can promote the healing time of ulcers and relieve the pain, but most of the time can not decrease the frequency of RAS relapse. However, for continuous RAS, treatment with systemic medication should be considered. Key words: reccurent, aphthous, stomatitis, RAS, treatment, systematic review. Received: 09 05 2022 Accepted for publishing: 24 03 2023 ¹UAB “SB dantu klinika”, LT49452 Kaunas, Lithuania ²Department of Dental and Oral Pathology, Lithuanian University of Health Sciences, Kaunas, Lithuania Address correspondence to Karolis Skučas, Faculty of Odontology, Medical Academy, Lithuanian University of Health Sciences, Taikos pr. 65-23, 50436 Kaunas, Lithuania. E-mail address: karolissk@gmail.com