REVIEWS

Odontogenic maxillary sinusitis: A review
Regimantas Simuntis, Ričardas Kubilius, Saulius Vaitkus
39-43

Reducing dental plaque formation and caries development. A review of current methods and implications for novel pharmaceuticals
Povilas Kalesinskas, Tomas Kačergius, Arvydas Ambrozaitis, Vytautė Pečiulienė, Dan Ericson
44-52

How various surgical protocols of the unilateral cleft lip and palate influence the facial growth and possible orthodontic problems? Which is the best timing of lip, palate and alveolus repair? Literature review
Giampietro Farronato, Laima Kairyte, Lucia Giannini, Guido Galbiati, Cinzia Maspero
53-60

SCIENTIFIC ARTICLES

Assessment of the lateral pterygoıd plate fractures durıng Le Fort I osteotomıes regardıng the angulatıon of the osteotome
Aydin Gulses, Hasan Ayberk Altug, Cenk Kılıc, Metin Sencımen
61-64

Self-reported oral health behavior and attitudes of dental and technology students in Lithuania
Ingrida M. Pacauskiene, Dalia Smailiene, Jolanta Siudikienė, Julija Savanevskyte, Irena Nedzelskiene
65-71

CASE REPORT

Non surgical treatment of Crouzon Syndrome
Cinzia Maspero, Lucia Giannini, Guido Galbiati, Laima Kairyte, Giampietro Farronato
72-80

Stomatologija 2014; 16 (2): 44-52 239 KB

Reducing dental plaque formation and caries development. A review of current methods and implications for novel pharmaceuticals

Povilas Kalesinskas, Tomas Kačergius, Arvydas Ambrozaitis, Vytautė Pečiulienė, Dan Ericson

Summary

Dental caries is an oral disease, which has a high worldwide prevalence despite the availability of various prophylactic means, including the daily use of fluoride toothpastes, water fluoridation, dental sealants, oral health educational programs and various antiseptic mouth-rinses. One important reason for this is uncontrolled increase in consumption of foods containing considerable sucrose concentration, especially among children. Sucrose is easily metabolized by oral bacteria (mostly streptococci) to acids and, subsequently, causing tooth decay or dental caries. In the oral ecosystem, streptococci principally reside on tooth surfaces forming biofilm. Important structural and binding materials of biofilm are glucan polymers synthesized by several isoforms of glucosyltransferase enzyme present in certain species of oral bacteria, including mutans group streptococci – Streptococcus mutans and Streptococcus sobrinus, which preferably colonize humans. Thus, there is a constant need to develop the methods and chemotherapeutics for improving oral health care and decreasing teeth decay through the suppression of cariogenic biofilm formation in the oral cavity. The aim of this paper was to review literature related to the pathogenesis of dental caries as well as currently existing and experimental pharmaceutical substances used for prevention of this process.

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¹Institute of Odontology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania

²Clinic of Infectious and Chest Diseases, Dermatovenereology and Allergology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania

³Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania

⁴Department of Cariology, Faculty of Odontology, Malmö University, Malmö, Sweden

Povilas Kalesinskas^{1, 2} – D.D.S., assist. prof.

Tomas Kačergius³ – D.D.S., PhD, assoc. prof.

Arvydas Ambrozaitis² – M.D., PhD, prof.

Vytautė Pečiulienė¹ – D.D.S., PhD, prof.

Dan Ericson⁴ – D.D.S., PhD, prof.

Address correspondence to Dr. Povilas Kalesinskas, Institute of Odontology, Faculty of Medicine, Vilnius University, Zalgirio str. 115, LT-08217 Vilnius, Lithuania. E-mail address: p.kalesinskas@gmail.com