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Stomatologija 2011; 13 (2): 35-41 289 KB

Proliferative potential in benign mixed salivary gland tumors and its value in primary and recurrent neoplasms

Anna Kazanceva, Valerie Groma, Liene Smane, Egils Kornevs, Uldis Teibe

Summary

Objective. Mixed salivary gland tumors are characterized by a marked diversity in the cell proliferation. It course in the stromal component, and, especially in recurrent neoplasms, is not completely understood. This study evaluated cell proliferative potential, its value and the clinical course of primary and recurrent salivary gland pleomorphic adenomas (PA).

Materials and methods. 322 benign salivary gland tumors were used in this study. The cell proliferation was estimated by Ki-67 expression levels.

Results. Ki-67 immunoreactivity showed a wide range of spectra; in the epithelial and stromal type of PA the cell proliferation had the value from 0.07±0.03 (95% CI 0.01-0.14) to 4.81±0.60 (95% CI 3.61-6.02) and from 0 to 0.79±0.11 (95% CI 0.57-1.00), respectively. The Ki-67 value was higher in recurrent tumors compared with primary, and the mean number of Ki-67-positive cells per visual microscopic field constituted 2.14±1.60 (95% CI 1.47-2.47) comparing with 1.43 (95% CI 0.97-1.55) revealed in primary tumors.

Conclusion. Cell proliferation values correlate with a recurrence of neoplasm, and elevation of proliferation potential in the stromal component of recurrent PA is indicative of clinical course change for the worse.

Key words: cell proliferation, tumors, salivary glands.

Received: 30 09 2010

Accepted for publishing: 24 06 2011

¹Institute of Anatomy and Anthropology, Riga Stradins University, Riga, Latvia

²Institute of Stomatology, Department of Maxillofacial Surgery, Riga Stradins University, Riga, Latvia

³Department of Medical Physics and Statistics, Riga Stradins University, Riga, Latvia

Anna Kazanceva² – Dr., PhD student

Valerie Groma¹ – Dr. med., Dr. hab. med., Assoc. prof., Head of Laboratory of Electron Microscopy of Institute of Anatomy and Anthropology

Liene Smane¹ – Assist.

Egils Kornevs² – Dr. med., Dr. hab. med., Assoc. prof.

Uldis Teibe³ – Dr. biol., Prof., Head of Department of Medical Physics and Statistics

Address correspondence to Dr. Valerie Groma, Institute of Anatomy and Anthropology, Riga Stradins University, Dzirciema 16, Riga LV 1007, Latvia.
E-mail address: aaisel@rsu.lv



	Baltic Dental and Maxillofacial Journal

June, 2011, Vol. 13, No. 2 CONTENTS SCIENTIFIC ARTICLES Proliferative potential in benign mixed salivary gland tumors and its value in primary and recurrent neoplasms Anna Kazanceva, Valerie Groma, Liene Smane, Egils Kornevs, Uldis Teibe 35-41 Relationship between radiographic changes in the temporomandibular joint and bone mineral density: A population based study Oksana Jagur, Mart Kull, Edvitar Leibur, Riina Kallikorm, Dagmar Loorits, Margus Lember, Ülle Voog – Oras 42-48 Prognostic factors and epidemiological characteristics of cutaneous and mucosal head and neck melanoma Anna Berzina, Kristine Azarjana, Ingrida Cema, Dace Pjanova, Alexander Rivosh 49-54 Comparative analysis of CRT Buffer, GC Saliva Check Buffer tests and laboratory titration to evaluate saliva buffering capacity Ilze Maldupa, Anda Brinkmane, Anna Mihailova 55-61 The relation between oral hygiene skills and the prevalence of dental caries among 4 - 6-yearoldchildren Jaunė Razmienė, Giedrius Vanagas, Eglė Bendoraitienė, Aurelija Vyšniauskaitė 62-67 Evaluation of oral health status of retirement-age population in Latvia Aldis Vidzis, Ingrida Cema, Ingrida Krasta, Anda Brinkmane, Imants Kalnins 68-72 © 2011 Stomatologija		Stomatologija 2011; 13 (2): 35-41 289 KB Proliferative potential in benign mixed salivary gland tumors and its value in primary and recurrent neoplasms Anna Kazanceva, Valerie Groma, Liene Smane, Egils Kornevs, Uldis Teibe Summary Objective. Mixed salivary gland tumors are characterized by a marked diversity in the cell proliferation. It course in the stromal component, and, especially in recurrent neoplasms, is not completely understood. This study evaluated cell proliferative potential, its value and the clinical course of primary and recurrent salivary gland pleomorphic adenomas (PA). Materials and methods. 322 benign salivary gland tumors were used in this study. The cell proliferation was estimated by Ki-67 expression levels. Results. Ki-67 immunoreactivity showed a wide range of spectra; in the epithelial and stromal type of PA the cell proliferation had the value from 0.07±0.03 (95% CI 0.01-0.14) to 4.81±0.60 (95% CI 3.61-6.02) and from 0 to 0.79±0.11 (95% CI 0.57-1.00), respectively. The Ki-67 value was higher in recurrent tumors compared with primary, and the mean number of Ki-67-positive cells per visual microscopic field constituted 2.14±1.60 (95% CI 1.47-2.47) comparing with 1.43 (95% CI 0.97-1.55) revealed in primary tumors. Conclusion. Cell proliferation values correlate with a recurrence of neoplasm, and elevation of proliferation potential in the stromal component of recurrent PA is indicative of clinical course change for the worse. Key words: cell proliferation, tumors, salivary glands. Received: 30 09 2010 Accepted for publishing: 24 06 2011 ¹Institute of Anatomy and Anthropology, Riga Stradins University, Riga, Latvia ²Institute of Stomatology, Department of Maxillofacial Surgery, Riga Stradins University, Riga, Latvia ³Department of Medical Physics and Statistics, Riga Stradins University, Riga, Latvia Anna Kazanceva² – Dr., PhD student Valerie Groma¹ – Dr. med., Dr. hab. med., Assoc. prof., Head of Laboratory of Electron Microscopy of Institute of Anatomy and Anthropology Liene Smane¹ – Assist. Egils Kornevs² – Dr. med., Dr. hab. med., Assoc. prof. Uldis Teibe³ – Dr. biol., Prof., Head of Department of Medical Physics and Statistics Address correspondence to Dr. Valerie Groma, Institute of Anatomy and Anthropology, Riga Stradins University, Dzirciema 16, Riga LV 1007, Latvia. E-mail address: aaisel@rsu.lv