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Stomatologija 2010; 12 (4): 99-104 94 KB

Today’s understanding about bone aging

Maris Grzibovskis, Mara Pilmane, Ilga Urtane

Summary

Patient`s age is an important factor in orthodontic treatment. There are many studies about bone aging from the aspects of osteoporosis and other bone diseases. Both, aging and osteoporosis are associated problems and have a great importance in relation to their incidence. But not only osteoporosis or other bone related diseases are issue for many studies, because the knowledge of bone pathophysiology and diagnostics with signaling molecules makes it possible to predict treatment outcome and specific cell targeted pharmacology. In recent years immunohistological studies had become very popular in all fields of medicine including orthodontics, too. The question we tried to answer in this literature mini-review was - what kind of immunohistological studies were done from the aspect of bone aging in relation to patient`s age and orthodontic treatment?

Search on Cochrane Library, PubMed, Science Direct, and DynaMed data bases by keywords: Alveolar bone aging, RANK, RANKL, OPG, MMP-1, MMP-8, IL-1, IL-6, TNF-α, TNF-β, and BM, resulted with 147 full-text articles; from them 90 met the criteria, 30 were reviews, and only in 22 articles from 60 bone aging from the aspect of signaling molecules were discussed. Interestingly, only 2 articles (Cei 2006 and Zhang 2003) were related to alveolar bone, and none studied it from the orthodontic point of view. Patient`s age plays an important role in orthodontic treatment, because of the bone response to mechanical loading. It is in accordance to clinical studies, or alike, that tooth movement in younger patient occurs much faster than in adults, but the question which factors are responsible for the process still remains.

Key words: Alveolar bone aging, RANK, RANKL, OPG, MMP-1, MMP-8, IL-1, IL-6, TNF-α, TNF-β, BMP.

Received: 30 07 2010

Accepted for publishing: 28 12 2010

¹Department of Orthodontics, Institute of Stomatology, Riga Stradins University, Riga, Latvia

²Institute of Anatomy, Riga Stradins University, Riga, Latvia

Maris Grzibovskis¹ – D.D.S

Mara Pilmane² – Dr. med., Dr. hab. med.

Ilga Urtane¹ – D.D.S., Dr. med., prof.

Address correspondence to Dr. Maris Grzibovskis 20 Dzirciema Street, Riga, Latvia, LV 1007.

E-mail address: mgmaris@inbox.lv



	Baltic Dental and Maxillofacial Journal

December, 2010, Vol. 12, No. 4 CONTENTS REVIEW Today’s understanding about bone aging Maris Grzibovskis, Mara Pilmane, Ilga Urtane 99-104 SCIENTIFIC ARTICLES Epidemiologic factors causing cleft lip and palate and their regularities of occurrence in Estonia Triin Jagomagi, Marianne Soots, Mare Saag 105-108 Analysis of the crown fractures and factors affecting pulp survival due to dental trauma Ilona Viduskalne, Ruta Care 109-115 Microflora of root filled teeth with apical periodontitis in Latvian patients Anda Mindere, Rita Kundzina, Vizma Nikolajeva, Daina Eze, Zaiga Petrina 116-121 CLINICAL CASE REPORTS An expanded odontogenic myxoma in maxilla Bruno Ramos Chrcanovic, Márcio Bruno Figueiredo do Amaral, Helenice de Andrade Marigo, Belini Freire-Maia 122-128 © 2010 Stomatologija		Stomatologija 2010; 12 (4): 99-104 94 KB Today’s understanding about bone aging Maris Grzibovskis, Mara Pilmane, Ilga Urtane Summary Patient`s age is an important factor in orthodontic treatment. There are many studies about bone aging from the aspects of osteoporosis and other bone diseases. Both, aging and osteoporosis are associated problems and have a great importance in relation to their incidence. But not only osteoporosis or other bone related diseases are issue for many studies, because the knowledge of bone pathophysiology and diagnostics with signaling molecules makes it possible to predict treatment outcome and specific cell targeted pharmacology. In recent years immunohistological studies had become very popular in all fields of medicine including orthodontics, too. The question we tried to answer in this literature mini-review was - what kind of immunohistological studies were done from the aspect of bone aging in relation to patient`s age and orthodontic treatment? Search on Cochrane Library, PubMed, Science Direct, and DynaMed data bases by keywords: Alveolar bone aging, RANK, RANKL, OPG, MMP-1, MMP-8, IL-1, IL-6, TNF-α, TNF-β, and BM, resulted with 147 full-text articles; from them 90 met the criteria, 30 were reviews, and only in 22 articles from 60 bone aging from the aspect of signaling molecules were discussed. Interestingly, only 2 articles (Cei 2006 and Zhang 2003) were related to alveolar bone, and none studied it from the orthodontic point of view. Patient`s age plays an important role in orthodontic treatment, because of the bone response to mechanical loading. It is in accordance to clinical studies, or alike, that tooth movement in younger patient occurs much faster than in adults, but the question which factors are responsible for the process still remains. Key words: Alveolar bone aging, RANK, RANKL, OPG, MMP-1, MMP-8, IL-1, IL-6, TNF-α, TNF-β, BMP. Received: 30 07 2010 Accepted for publishing: 28 12 2010 ¹Department of Orthodontics, Institute of Stomatology, Riga Stradins University, Riga, Latvia ²Institute of Anatomy, Riga Stradins University, Riga, Latvia Maris Grzibovskis¹ – D.D.S Mara Pilmane² – Dr. med., Dr. hab. med. Ilga Urtane¹ – D.D.S., Dr. med., prof. Address correspondence to Dr. Maris Grzibovskis 20 Dzirciema Street, Riga, Latvia, LV 1007. E-mail address: mgmaris@inbox.lv