www.sbdmj.com - Stomatologija - Baltic Dental and Maxillofacial Journal

Stomatologija 2023; 25 (4): 91-6 366 KB

Mononuclear cell phagocytosis in giant cell lesions of the jaws

Sebastião Silvério Sousa-Neto¹, Gimenna Barbosa Pereira², Elismauro Francisco Mendonça³, Allisson Filipe Lopes Martins²

Summary

Background and objective. The central giant cell lesion (CGCL) is a benign intraosseous lesion that may resemble other giant cell-rich lesions, such as the peripheral giant cell lesion (PGCL). This lesion may be classified as aggressive or non-aggressive according to clinical and radiographic criteria, however, there is no biological marker that may help to define the CGCL based on the biological behavior. In this context, stromal cell phagocytosis has been described as an event related to aggressive lesions, however, only a few studies have investigated this phenomenon in CGCL. The aim of this study was to compare mononuclear cell phagocytosis by the multinucleated giant cells between aggressive, non-aggressive CGCL and PGCL.

Material and methods. Thirty-three cases of CGCL, 10 aggressive and 23 non-aggressive, and 20 cases of PGCL were included in this study. Phagocytosis events were evaluated in five consecutive microscopic fields from histological sections, stained with hematoxylin and eosin. The ratio between the numbers of phagocytosis/mm² and the total number of multinucleated giant cells/mm² was calculated.

Results. Phagocytosis was observed in the multinucleated giant cells of all cases. The density of phagocytosis/mm² in relation to giant cells/mm² was higher in the CGCL than in the PGCL. In addition, aggressive CGCL showed higher phagocytosis events when compared to the non-aggressive variant.

Conclusion. Our results suggest that the aggressiveness of multinucleated giant cell lesions of the jaws may be related to the number of phagocytosis events in the lesion.

Key words: fibro-osseous lesions, giant cell granuloma, peripheral giant cell lesion, central giant cell granuloma, phagocytosis.

Received: 13 04 2022

Accepted for publishing: 27 12 2023

¹Universidade de Campinas (UNICAMP), Piracicaba Dental School, Oral Diagnosis Department, São Paulo, Brazil

²Universidade Evangélica de Goiás, Departamento de Diagnóstico Bucal, Anápolis, Goiás, Brazil

³Universidade Federal de Goiás – UFG, School of Dentistry, Department of Stomatology (Oral Pathology), Goiânia, Goiás, Brazil

Address correspo ndence to Allisson Filipe Lopes Martins, Universidade Evangélica de Goiás, Department of Oral Diagnosis, Avenida Universitária, Km 3, 5, s/n, Cidade Universitária, Anápolis, Goiás, Brazil. ZIP-code: 75083-515.

E-mail address: allissonfilipe@hotmail.com



	Baltic Dental and Maxillofacial Journal

2023, Vol. 25, No. 4 CONTENTS SCIENTIFIC ARTICLE Mononuclear cell phagocytosis in giant cell lesions of the jaws Sebastião Silvério Sousa-Neto, Gimenna Barbosa Pereira, Elismauro Francisco Mendonça, Allisson Filipe Lopes Martins 91-96 REVIEW Effect of orthognathic surgery on temporomandibular joint pain. A systematic review Augustinas Buškus, Greta Milvydaitė, Jan Pavel Rokicki 97-102 CASE REPORTS Unveiling the surge of subcutaneous dirofilariasis in lithuania: A comprehensive exploration of a zoonotic parasite's emergence, clinical manifestations, and management strategies. Brief literature review and three reports of cases Audra Janovskiene, Kornelijus Micka, Algirdas Lukosiunas, Albinas Gervickas, Juozas Žilinskas, Dalius Sakavicius 103-108 Single ultra-short implant rehabilitation of posterior atrophic maxillae with 5 years follow-up Zhurakivska Khrystyna, Alberto Dedola, Michele Laurenziello, Montaruli Graziano 109-112 © 2024 Stomatologija		Stomatologija 2023; 25 (4): 91-6 366 KB Mononuclear cell phagocytosis in giant cell lesions of the jaws Sebastião Silvério Sousa-Neto¹, Gimenna Barbosa Pereira², Elismauro Francisco Mendonça³, Allisson Filipe Lopes Martins² Summary Background and objective. The central giant cell lesion (CGCL) is a benign intraosseous lesion that may resemble other giant cell-rich lesions, such as the peripheral giant cell lesion (PGCL). This lesion may be classified as aggressive or non-aggressive according to clinical and radiographic criteria, however, there is no biological marker that may help to define the CGCL based on the biological behavior. In this context, stromal cell phagocytosis has been described as an event related to aggressive lesions, however, only a few studies have investigated this phenomenon in CGCL. The aim of this study was to compare mononuclear cell phagocytosis by the multinucleated giant cells between aggressive, non-aggressive CGCL and PGCL. Material and methods. Thirty-three cases of CGCL, 10 aggressive and 23 non-aggressive, and 20 cases of PGCL were included in this study. Phagocytosis events were evaluated in five consecutive microscopic fields from histological sections, stained with hematoxylin and eosin. The ratio between the numbers of phagocytosis/mm² and the total number of multinucleated giant cells/mm² was calculated. Results. Phagocytosis was observed in the multinucleated giant cells of all cases. The density of phagocytosis/mm² in relation to giant cells/mm² was higher in the CGCL than in the PGCL. In addition, aggressive CGCL showed higher phagocytosis events when compared to the non-aggressive variant. Conclusion. Our results suggest that the aggressiveness of multinucleated giant cell lesions of the jaws may be related to the number of phagocytosis events in the lesion. Key words: fibro-osseous lesions, giant cell granuloma, peripheral giant cell lesion, central giant cell granuloma, phagocytosis. Received: 13 04 2022 Accepted for publishing: 27 12 2023 ¹Universidade de Campinas (UNICAMP), Piracicaba Dental School, Oral Diagnosis Department, São Paulo, Brazil ²Universidade Evangélica de Goiás, Departamento de Diagnóstico Bucal, Anápolis, Goiás, Brazil ³Universidade Federal de Goiás – UFG, School of Dentistry, Department of Stomatology (Oral Pathology), Goiânia, Goiás, Brazil Address correspo ndence to Allisson Filipe Lopes Martins, Universidade Evangélica de Goiás, Department of Oral Diagnosis, Avenida Universitária, Km 3, 5, s/n, Cidade Universitária, Anápolis, Goiás, Brazil. ZIP-code: 75083-515. E-mail address: allissonfilipe@hotmail.com