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Stomatologija 2023; 25 (3): 78-83 344 KB

Cytological diagnosis of Langerhans cell histiocytosis. Apropos 2 cases

Eleni Thodou¹, Konstantina Papaharalambous², Eleni Lappa³, Irini Skliva³, Ekaterini Diamanti³, Giannis Kokkinakis³, Eleni Konsolaki⁴, Dimitrios Tamiolakis³

Summary

Langerhans cell histiocytosis (LCH) comprises a wide spectrum of clinical presentations in children and adults, ranging from favorable lesions to aggressive disseminated disease. We present 2 cases where cytology introduced the diagnosis of LCH in the appropriate clinicoradioliogical settings. Cytology can serve accurately in LCH interpretation based on the characteristic cytomorphology and selected immunocytochemistry, so unwarranted biopsy can be overruled and treatment can be adjusted largely where histopathology services are unavailable. Diagnosis may be difficult in cases with scant or insufficient cellular material.

Key words: Langerhans cell histiocytosis, cytology, histopathology, langerin, CD1a, S-100.

Received: 28 03 2023

Accepted for publishing: 25 09 2023

¹Department of Pathology, Faculty of Medicine University of Thessaly, Greece

²Department of Pathology, IASO Thessalias, Greece

³Departments of Pathology, Faculty of Medicine, University of Crete, Greece

⁴Department of Maxillofacial Surgery, University Hospital of Heraklion, Crete, Greece

Address correspondence to Dimitrios Tamiolakis, Department of Pathology-Cytopathology, University Hospital of Heraklion, Voutes, Heraklion, Crete, Greece.

E-mail address: dtamiolakis@yahoo.com



	Baltic Dental and Maxillofacial Journal

2023, Vol. 25, No. 3 CONTENTS SCIENTIFIC ARTICLE Multiple-tooth autotransplantation patients: Long-term (4–8 years) results of treatment Janne Tiigimäe-Saar 63-70 REVIEW Odontogenic sinusitis: causes, symptoms and treatment. A review of current literature and concepts Žygimantas Petronis, Audra Janovskienė, Ričardas Kubilius, Juozas Žilinskas, Marijus Leketas 71-78 CASE REPORTS Cytological diagnosis of Langerhans cell histiocytosis. Apropos 2 cases Eleni Thodou, Konstantina Papaharalambous, Eleni Lappa, Irini Skliva, Ekaterini Diamanti, Giannis Kokkinakis, Eleni Konsolaki, Dimitrios Tamiolakis 79-83 Intraoral surgical treatment of large complex odontoma with technology support in planning Renato Torres Augusto Neto, Júlio César Silva de Oliveira, Luiz Henrique Soares Torres, Deborah Laurindo Pereira Santos, Marisa Aparecida Cabrini Gabrielli, Valfrido Antônio Pereira Filho 84-88 © 2024 Stomatologija		Stomatologija 2023; 25 (3): 78-83 344 KB Cytological diagnosis of Langerhans cell histiocytosis. Apropos 2 cases Eleni Thodou¹, Konstantina Papaharalambous², Eleni Lappa³, Irini Skliva³, Ekaterini Diamanti³, Giannis Kokkinakis³, Eleni Konsolaki⁴, Dimitrios Tamiolakis³ Summary Langerhans cell histiocytosis (LCH) comprises a wide spectrum of clinical presentations in children and adults, ranging from favorable lesions to aggressive disseminated disease. We present 2 cases where cytology introduced the diagnosis of LCH in the appropriate clinicoradioliogical settings. Cytology can serve accurately in LCH interpretation based on the characteristic cytomorphology and selected immunocytochemistry, so unwarranted biopsy can be overruled and treatment can be adjusted largely where histopathology services are unavailable. Diagnosis may be difficult in cases with scant or insufficient cellular material. Key words: Langerhans cell histiocytosis, cytology, histopathology, langerin, CD1a, S-100. Received: 28 03 2023 Accepted for publishing: 25 09 2023 ¹Department of Pathology, Faculty of Medicine University of Thessaly, Greece ²Department of Pathology, IASO Thessalias, Greece ³Departments of Pathology, Faculty of Medicine, University of Crete, Greece ⁴Department of Maxillofacial Surgery, University Hospital of Heraklion, Crete, Greece Address correspondence to Dimitrios Tamiolakis, Department of Pathology-Cytopathology, University Hospital of Heraklion, Voutes, Heraklion, Crete, Greece. E-mail address: dtamiolakis@yahoo.com