Baltic Dental and Maxillofacial Journal
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September, 2021, Vol. 23, No. 3

CONTENTS

REVIEW

The effect of botox for the correction of the gummy smile: A systematic review
Augustė Razmaitė, Giedrė Trakinienė
63-68

SCIENTIFIC ARTICLES

Immediate implant supported prosthodontic treatment of the edentulous jaw with additional implant stabilization
Roman А. Rozov
69-74

REVIEW

Could saliva play a role in controlling the Covid-19 pandemic?
Anna Papadopoulou, Despina Tounta, Christina Tesseromatis
75-79

SCIENTIFIC ARTICLES

Knowledge, attitude and practice of dental house surgeons and undergraduate students towards radiation safety and protection: A questionnaire based survey
Kirthana Muthu A/P Shanmugam, Ananya Madival, Supriya Bhat, Siti Dzulaikha Amalina Binti Jelani
80-85

CASE REPORTS

Is there an association with Wilson’s disease and multiple tongue dysplasia lesions and in situ carcinoma? A case-report based literature review
Tatsis Dimitris, Baliaka Aggeliki, Antoniades Konstantinos
86-89

Canalicular adenoma of minor salivary gland. Report of a case and a brief review of the literature
Karakostas Panagiotis, Matiakis Apostolos, Anagnostou Eleftherios, Poulopoulos Athanasios
90-92

© 2021 Stomatologija

Stomatologija 2021; 23 (3): 86-9 176 KB

Is there an association with Wilson’s disease and multiple tongue dysplasia lesions and in situ carcinoma? A case-report based literature review

Tatsis Dimitris1, Baliaka Aggeliki2, Antoniades Konstantinos3

Summary

Wilson’s Disease (WD) is a rare autosomal recessive hereditary disease with copper accumulation in the body, particularly the liver, brain and cornea. WD is widely treated with chelation agents who enable the copper excretion. Since high concentrations of copper are toxic, WD is associated with hepatocellular carcinoma and cholangiocarcinoma, with low incidence of other types of cancer. We present a case of a 33 year old man who was treated in the Oral and Maxillofacial Surgery Department of the Aristotle University of Thessaloniki with multiple dysplasia lesions and an in situ carcinoma of the tongue, which is to our knowledge the first case report of oral lesions to a patient with WD. Literature is reviewed on copper levels on patients with head and neck cancer, and on chelation agents and their effect on cancer cells.

Key words: oral cancer, Wilson’s disease, precancerous lesions, copper.

Received: 04 03 2020

Accepted for publishing: 24 09 2021


1Department of Oral and Maxillofacial Surgery, General Hospital G. Papanikolaou, Thessaloniki, Greece

2Department of Pathology, General Hospital G. Papanikolaou, Thessaloniki, Greece

3Department of Oral and Maxillofacial Surgery, Aristotle University of Thessaloniki, Thessaloniki, Greece

Address correspondence to Tatsis Dimitris, Department of Oral and Maxillofacial Surgery, General Hospital Georgios Papanikolaou Exochi, 57010, Greece. E

-mail address: dtatsis@outlook.com