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Stomatologija 2020; 22 (2): 49-53 198 KB

Enamel matrix derivate induces periodontal regeneration by activating growth factors: A review

Rūta Kulakauskienė1, Rokas Aukštakalnis1, Renata Šadzevičienė2

Summary

Objective. The aim of this article is to review the effect of enamel matrix derivate (EMD) on growth factors activation for periodontal regeneration.

Material and methods. Online databases, such as PubMed, Cochrane Library, PMC, Science Direct were searched by using the following keywords in various combinations: emdogain, periodontal regeneration, growth factors, transforming growth factor, bone morphogenetic protein, fibroblast growth factor and vascular endothelial growth factors. All studies fulfilling the selection criteria were carefully reviewed for the focused question: "Does enamel matrix derivate induces the activity of growth factors, important in periodontal regeneration?“.

Results. 1378 articles were found in the databases using keywords. After duplicate citations screened, inclusion/exclusion criteria applied, excluded articles after titles, summaries and full-text reading 14 articles were included in the literature review.

Conclusion. Enamel matrix derivate (EMD) was found to have a possitive effect on periodontal tissue regneration. By stimulating secretion and activating functions of growth factors, such as transforming growth factor-β (TGF-β), bone morphogenetic proteins (BMP), vascular endothelial growth factors (VEGF) and fibroblast growth factor-2 (FGF-2), EMD induces production of new alveolar bone, new root cementum and functionl periodontal ligament (PDL) and new blood vessels formation in periodontal area. Due to this production, the probing depth of periodontal pocket is being reduced.

Key words: emdogain; enamel matrix derivate; growth factors; periodontal regeneration.

Received: 29 04 2018

Accepted for publishing: 24 06 2020

¹Faculty of Odontology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania

²Clinic of Dental and Oral Pathology, Faculty of Odontology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania

Address correspondence to Rūta Kulakauskienė, Faculty of Odontology, Medical Academy, Lithuanian University of Health Sciences, Žemaičių g. 23A, Jonava 55201, Lithuania.

E-mail: simrta@gmail.com



	Baltic Dental and Maxillofacial Journal

June, 2020, Vol. 22, No. 2 CONTENTS ACTUAL REPORT Coronavirus Disease-2019 and dental practice: A project on the use of ozonized water in the water circuit of the dental armchair Elena Bardellini, Francesca Amadori, Federica Veneri, Giulio Conti, Alessandra Majorana 35-38 SCIENTIFIC ARTICLES Head and face injuries in elderly patients victims of fall. A single trauma center analysis Alidianne Fábia Cabral Cavalcanti, Sabrina da Silva Sousa Formiga, Taynná Dantas de Arruda, Rogéria Máximo de Lavôr, Christiane Leite Cavalcanti, Catarina Ribeiro Barros de Alencar, Sergio d’Avila, Alessandro Leite Cavalcanti 39-43 REVIEWS Stress and associated factors among dentists Guostė Antanavičienė, Monika Zaleckytė, Julija Narbutaitė 44-48 Enamel matrix derivate induces periodontal regeneration by activating growth factors: A review Rūta Kulakauskienė, Rokas Aukštakalnis, Renata Šadzevičienė 49-53 SCIENTIFIC ARTICLES Heritability of mandibular asymmetries in sagittal direction: A cephalometric study Ingrida Rakauskaite, Vilma Svalkauskiene, Zygimantas Labanauskas, Donata Juozėnaitė, Giedrė Trakinienė, Justina Vaiciuniene 54-57 REVIEWS Use of platelet-rich fibrin versus connective tissue graft in treatment of gingival recessions: Literature review Aušra Balčiūnaitė, Henrikas Rusilas, Juozas Žilinskas 58-64 © 2020 Stomatologija		Stomatologija 2020; 22 (2): 49-53 198 KB Enamel matrix derivate induces periodontal regeneration by activating growth factors: A review Rūta Kulakauskienė1, Rokas Aukštakalnis1, Renata Šadzevičienė2 Summary Objective. The aim of this article is to review the effect of enamel matrix derivate (EMD) on growth factors activation for periodontal regeneration. Material and methods. Online databases, such as PubMed, Cochrane Library, PMC, Science Direct were searched by using the following keywords in various combinations: emdogain, periodontal regeneration, growth factors, transforming growth factor, bone morphogenetic protein, fibroblast growth factor and vascular endothelial growth factors. All studies fulfilling the selection criteria were carefully reviewed for the focused question: "Does enamel matrix derivate induces the activity of growth factors, important in periodontal regeneration?“. Results. 1378 articles were found in the databases using keywords. After duplicate citations screened, inclusion/exclusion criteria applied, excluded articles after titles, summaries and full-text reading 14 articles were included in the literature review. Conclusion. Enamel matrix derivate (EMD) was found to have a possitive effect on periodontal tissue regneration. By stimulating secretion and activating functions of growth factors, such as transforming growth factor-β (TGF-β), bone morphogenetic proteins (BMP), vascular endothelial growth factors (VEGF) and fibroblast growth factor-2 (FGF-2), EMD induces production of new alveolar bone, new root cementum and functionl periodontal ligament (PDL) and new blood vessels formation in periodontal area. Due to this production, the probing depth of periodontal pocket is being reduced. Key words: emdogain; enamel matrix derivate; growth factors; periodontal regeneration. Received: 29 04 2018 Accepted for publishing: 24 06 2020 ¹Faculty of Odontology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania ²Clinic of Dental and Oral Pathology, Faculty of Odontology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania Address correspondence to Rūta Kulakauskienė, Faculty of Odontology, Medical Academy, Lithuanian University of Health Sciences, Žemaičių g. 23A, Jonava 55201, Lithuania. E-mail: simrta@gmail.com