Baltic Dental and Maxillofacial Journal
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March, 2019, Vol. 21, No. 1



Diagnostic methods and treatment strategies of impacted maxillary canines: A literature review
Viktorija Grybienė, Donata Juozėnaitė, Kristina Kubiliūtė


A population based study of multiple myeloma patients with medication-related osteonecrosis of the jaw
Daiga Auzina, Anda Slaidina, Marina Sevastjanova, Renars Erts, Aivars Lejnieks, Sandra Lejniece


Comparison of pressure pain threshold between muscles in the contracted and relaxed state in patients with myofascial pain: a cross-sectional study
Rodrigo Lorenzi Poluha, Matheus Cavassani Pereira, Rafael Dos Santos Silva



Types of root resorptions related to orthodontic treatment
Giedrė Ruškytė, Donata Juozėnaitė, Kristina Kubiliūtė



Orthodontic treatment complexity, outcome and need among school age patients of Lithuanian university of health sciences clinic of orthodontics
Rokas Liausas, Zygimantas Labanauskas, Vilma Svalkauskiene, Dalia Smailiene, Justina Vaiciuniene


© 2019 Stomatologija

Stomatologija 2019; 21 (1): 13-7 237 KB

A population based study of multiple myeloma patients with medication-related osteonecrosis of the jaw

Daiga Auzina1, 2, Anda Slaidina1, 3, Marina Sevastjanova1, 3, Renars Erts4, Aivars Lejnieks1, Sandra Lejniece1, 2


Objective. Medication-related osteonecrosis of the jaw (MRONJ) is a rare complication of antiresorptive or antiangiogenetic therapy that manifests as an exposed bone with clinical signs of infection, persisting for more than 8 weeks, without history of radiation therapy or metastases to the jaws. The aim of the study was to describe the incidence, risk factors, staging process and clinical course of MRONJ in patients with multiple myeloma (MM).

Materials and methods. We retrospectively analyzed all (126) newly diagnosed MM patients at Riga East Clinical University Hospital (Riga. Latvia) from June 2014 to June 2017.

Results. Among 88 MM patients treated with bisphosphonates (BP), 6 (6.8%) patients developed MRONJ. All six patients received intravenous nitrogen-containing BPs. The average time until MRONJ manifestation was under two years. For our patients the severity of MRONJ was stage I in two, stage II in three, and stage III in one patient. Five patients had MRONJ of mandibula and one of maxilla. All patients with MRONJ had undergone a dental extraction or a trauma before the development of MRONJ.

Conclusion. We found that MRONJ correlated with the patient’s age. The average time until MRONJ manifestation in reserach group is 2 years. One of triggerring MRONJ factors are tooth extraction or trauma.

Key words: medication-related osteonecrosis of the jaw, bisphosphonates, multiple myeloma, osteonecrosis.

Received: 18 05 2018

Accepted for publishing: 20 03 2019

1Rīga Stradiņš University. Riga. Latvia

2Riga East Clinical University Hospital. Riga. Latvia

3Riga Stradiņš University Institute of Stomatology. Riga. Latvia

4University of Latvia. Faculty of medicine. Riga. Latvia

Address correspondence to Daiga Auzina. Faculty of medicine. University of Latvia, 4 Hipokrata Street. Riga. Latvia.

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