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Stomatologija 2013; 15 (1): 32-6 226 KB

5-aminolevulinic acid based Photodynamic therapy for basal cell carcinoma: A 10-years follow-up study

Žans Griškjans, Aleksands Derjabo, Ingrīda Čēma

Summary

Objective. This article presents long-term follow-up after use of topical photodynamic therapy (PDT) for basal cell carcinoma. PDT is treatment option for different tumors, involving use of specific agent which is activated by visible light and results in tissue destruction.

Materials and methods. Overall 20 patients with 29 tumors were treated at the Latvian Oncology Center. Two illumination techniques were used: superficial for smaller lesions and multifiber contact for nodular tumors. Clinical outcome was evaluated at 1, 7, 44 months and 10 years after procedure.

Results. By 10 year follow up, there were 2 tumor recurrences and in one case there was tumor residual tissue after first PDT treatment. Overall after ten years follow-up complete response was 80% of cases.

Conclusion. Data in this study supports hypothesis that PDT could be used for the treatment of non-invasive (superficial and nodular) basal cell carcinoma. Results in this study correspond with similar long-term follow-up studies.

Key words: photodynamic therapy, 5-aminolevulinic acid, basal cell carcinoma, long-term follow-up.

Received: 24 05 2012

Accepted for publishing: 22 03 2013

¹Faculty of Stomatology, Riga Stradin’s University, Riga, Latvia

²Latvian Oncology Center, Riga, Latvia

Žans Griškjans¹ – post-graduate student

Aleksands Derjabo² – doctoral student

Ingrīda Čēma¹ – D.D.S., Dr. hab. med, prof.

Address correspondence to Žans Griškjans, Dammes 2-49, Riga Stradiņš University, Riga, Latvia. E-mail address: z.griskjans@gmail.com



	Baltic Dental and Maxillofacial Journal

March, 2013, Vol. 15, No. 1 CONTENTS SCIENTIFIC ARTICLES Caries prevalence and determinants among 12-year-olds in North-West Russia and Northern Norway Natalia Koposova, Harald M. Eriksen, Eeva Widström, Bjørn Helge Handegård, Mikhail Pastbin, Roman Koposov 3-11 Dynamical changes of occlusion and articulation during treatment of mandibular angle fractures Ausra Baltrusaityte, Algimantas Surna, Gaivile Pileicikiene, Ricardas Kubilius, Alvydas Gleiznys, Marijus Baltrusaitis 12-19 REVIEWS The Influence of the Design of Removable Dentures on Patient`s Voice Quality Kristine Broka, Aldis Vidzis, Juris Grigorjevs, Janis Sokolovs, Guntis Zigurs 20-25 SCIENTIFIC ARTICLES Children’s dental fear in relation to dental health and parental dental fear Jana Olak, Mare Saag, Sisko Honkala, Rita Nõmmela, Riina Runnel, Eino Honkala, Sára Karjalainen 26-31 5-aminolevulinic acid based Photodynamic therapy for basal cell carcinoma: A 10-years follow-up study Žans Griškjans, Aleksands Derjabo, Ingrīda Čēma 32-36 © 2013 Stomatologija		Stomatologija 2013; 15 (1): 32-6 226 KB 5-aminolevulinic acid based Photodynamic therapy for basal cell carcinoma: A 10-years follow-up study Žans Griškjans, Aleksands Derjabo, Ingrīda Čēma Summary Objective. This article presents long-term follow-up after use of topical photodynamic therapy (PDT) for basal cell carcinoma. PDT is treatment option for different tumors, involving use of specific agent which is activated by visible light and results in tissue destruction. Materials and methods. Overall 20 patients with 29 tumors were treated at the Latvian Oncology Center. Two illumination techniques were used: superficial for smaller lesions and multifiber contact for nodular tumors. Clinical outcome was evaluated at 1, 7, 44 months and 10 years after procedure. Results. By 10 year follow up, there were 2 tumor recurrences and in one case there was tumor residual tissue after first PDT treatment. Overall after ten years follow-up complete response was 80% of cases. Conclusion. Data in this study supports hypothesis that PDT could be used for the treatment of non-invasive (superficial and nodular) basal cell carcinoma. Results in this study correspond with similar long-term follow-up studies. Key words: photodynamic therapy, 5-aminolevulinic acid, basal cell carcinoma, long-term follow-up. Received: 24 05 2012 Accepted for publishing: 22 03 2013 ¹Faculty of Stomatology, Riga Stradin’s University, Riga, Latvia ²Latvian Oncology Center, Riga, Latvia Žans Griškjans¹ – post-graduate student Aleksands Derjabo² – doctoral student Ingrīda Čēma¹ – D.D.S., Dr. hab. med, prof. Address correspondence to Žans Griškjans, Dammes 2-49, Riga Stradiņš University, Riga, Latvia. E-mail address: z.griskjans@gmail.com