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Stomatologija 2024; 26 (1): 3-11 549 KB

Influence of primary tumor surgical margins on overall survival and local recurrence in patients with squamous cell carcinoma: meta-analysis

Abdulla Varoneckas¹, Mariam Varoneckaitė², Kotryna Rumšaitė², Marijus Leketas¹, Algirdas Lukošiūnas¹, Ričardas Kubilius¹

Summary

Aim. The aim of this meta-analysis was to determine the influence of surgical margins on the prognostic parameters of patients with oral squamous cell carcinoma.

Materials and methods. The literature review was carried out according to PRISMA principles and the database search was performed using following keywords: “Carcinoma, Squamous Cell (Mesh)”, “Squamous Cell Carcinoma of Head and Neck (Mesh)”, “Margins of Excision (Mesh)”. The review included studies with humans, published in English, no longer than 10 years ago, in which patients underwent resection of the primary tumour and the resections were examined histologically and the margins between healthy tissues and tumour were speicified.

Results. 5 of the included studies examined the impact of surgical margins on overall survival and 10 on local recurrence. In all 5 studies, surgical margins were considered an effective prognostic indicator for the overall survival. Examining the impact of surgical margins on the local recurrence, 7 studies indicated that it is an effective prognostic parameter. Quantitative analysis of the data revealed that a 3 mm surgical margin was safe.

Conclusions. Primary tumor surgical margins are an effective prognostic parameter for the overall survival and the local recurrence in patients with oral squamous cell carcinoma. 3 mm surgical margins can be concidered as a safe distance and minimum acceptable separation point between close and involved margins.

Key words: oral squamous cell carcinoma, primary tumor surgical margins, overall survival, local recurrence.

Received: 09 05 2023

Accepted for publishing: 20 03 2024

¹Department of Maxillofacial Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania

²Faculty of Odontology, Lithuanian University of Health Sciences, Kaunas, Lithuania

Address correspo ndence to Abdulla Varoneckas, Department of Maxillofacial Surgery, Lithuanian University of Health Sciences, Eivenių g. 2, LT-50161, Kaunas, Lithuania.

E-mail address: abudzio@gmail.com



	Baltic Dental and Maxillofacial Journal

2024, Vol. 26, No. 1 CONTENTS REVIEWS Influence of primary tumor surgical margins on overall survival and local recurrence in patients with squamous cell carcinoma: meta-analysis Abdulla Varoneckas, Mariam Varoneckaitė, Kotryna Rumšaitė, Marijus Leketas, Algirdas Lukošiūnas, Ričardas Kubilius 3-11 SCIENTIFIC ARTICLES Effect of the combination of chemical-physical pretreatments for bonding PEEK to resin composites Gretty Alonso-Martínez, Marine Ortiz-Magdaleno, Norma Verónica Zabala-Alonso, Paula Sánchez-Robles, Mariana Gutiérrez-Sánchez, Juan Carlos Flores-Arriaga, Gabriel Fernando Romo-Ramírez 12-17 REVIEWS Effect of a CAD-CAM sinus surgical template on the outcome of sinus augmentation. A systematic review Arezoo Mazaheri Nazarifar, Hamidreza Mohamad Sharifi, Maliheh Habib Khodaei, Amin Davoudi 18-23 CASE REPORTS Maxillary rhinosinusitis of odontogenic origin: a case series Tulio Bonna Pignaton, Rubens Spin-Neto, Guilherme José Pimentel Lopes de Oliveira, Carlos Eduardo de Almeida Ferreira 24-28 © 2024 Stomatologija		Stomatologija 2024; 26 (1): 3-11 549 KB Influence of primary tumor surgical margins on overall survival and local recurrence in patients with squamous cell carcinoma: meta-analysis Abdulla Varoneckas¹, Mariam Varoneckaitė², Kotryna Rumšaitė², Marijus Leketas¹, Algirdas Lukošiūnas¹, Ričardas Kubilius¹ Summary Aim. The aim of this meta-analysis was to determine the influence of surgical margins on the prognostic parameters of patients with oral squamous cell carcinoma. Materials and methods. The literature review was carried out according to PRISMA principles and the database search was performed using following keywords: “Carcinoma, Squamous Cell (Mesh)”, “Squamous Cell Carcinoma of Head and Neck (Mesh)”, “Margins of Excision (Mesh)”. The review included studies with humans, published in English, no longer than 10 years ago, in which patients underwent resection of the primary tumour and the resections were examined histologically and the margins between healthy tissues and tumour were speicified. Results. 5 of the included studies examined the impact of surgical margins on overall survival and 10 on local recurrence. In all 5 studies, surgical margins were considered an effective prognostic indicator for the overall survival. Examining the impact of surgical margins on the local recurrence, 7 studies indicated that it is an effective prognostic parameter. Quantitative analysis of the data revealed that a 3 mm surgical margin was safe. Conclusions. Primary tumor surgical margins are an effective prognostic parameter for the overall survival and the local recurrence in patients with oral squamous cell carcinoma. 3 mm surgical margins can be concidered as a safe distance and minimum acceptable separation point between close and involved margins. Key words: oral squamous cell carcinoma, primary tumor surgical margins, overall survival, local recurrence. Received: 09 05 2023 Accepted for publishing: 20 03 2024 ¹Department of Maxillofacial Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania ²Faculty of Odontology, Lithuanian University of Health Sciences, Kaunas, Lithuania Address correspo ndence to Abdulla Varoneckas, Department of Maxillofacial Surgery, Lithuanian University of Health Sciences, Eivenių g. 2, LT-50161, Kaunas, Lithuania. E-mail address: abudzio@gmail.com