|Baltic Dental and Maxillofacial Journal|
June, 2011, Vol. 13, No. 2
Relationship between radiographic changes in the temporomandibular joint and bone mineral density: A population based study
© 2011 Stomatologija
Stomatologija 2011; 13 (2): 35-41 289 KB
Proliferative potential in benign mixed salivary gland tumors and its value in primary and recurrent neoplasms
Anna Kazanceva, Valerie Groma, Liene Smane, Egils Kornevs, Uldis Teibe
Objective. Mixed salivary gland tumors are characterized by a marked diversity in the cell proliferation. It course in the stromal component, and, especially in recurrent neoplasms, is not completely understood. This study evaluated cell proliferative potential, its value and the clinical course of primary and recurrent salivary gland pleomorphic adenomas (PA).
Materials and methods. 322 benign salivary gland tumors were used in this study. The cell proliferation was estimated by Ki-67 expression levels.
Results. Ki-67 immunoreactivity showed a wide range of spectra; in the epithelial and stromal type of PA the cell proliferation had the value from 0.07±0.03 (95% CI 0.01-0.14) to 4.81±0.60 (95% CI 3.61-6.02) and from 0 to 0.79±0.11 (95% CI 0.57-1.00), respectively. The Ki-67 value was higher in recurrent tumors compared with primary, and the mean number of Ki-67-positive cells per visual microscopic field constituted 2.14±1.60 (95% CI 1.47-2.47) comparing with 1.43 (95% CI 0.97-1.55) revealed in primary tumors.
Conclusion. Cell proliferation values correlate with a recurrence of neoplasm, and elevation of proliferation potential in the stromal component of recurrent PA is indicative of clinical course change for the worse.
Key words: cell proliferation, tumors, salivary glands.
Received: 30 09 2010
Accepted for publishing: 24 06 2011
1Institute of Anatomy and Anthropology, Riga Stradins University, Riga, Latvia
2Institute of Stomatology, Department of Maxillofacial Surgery, Riga Stradins University, Riga, Latvia
3Department of Medical Physics and Statistics, Riga Stradins University, Riga, Latvia
Anna Kazanceva2 Dr., PhD student
Valerie Groma1 Dr. med., Dr. hab. med., Assoc. prof., Head of Laboratory of Electron Microscopy of Institute of Anatomy and Anthropology
Liene Smane1 Assist.
Egils Kornevs2 Dr. med., Dr. hab. med., Assoc. prof.
Uldis Teibe3 Dr. biol., Prof., Head of Department of Medical Physics and Statistics
Address correspondence to Dr. Valerie Groma, Institute of Anatomy and Anthropology, Riga Stradins University, Dzirciema 16, Riga LV 1007, Latvia.